Stretch-induced changes in constricted lung parenchymal strips: role of extracellular matrix
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چکیده
منابع مشابه
Stretch-induced changes in constricted lung parenchymal strips: role of extracellular matrix.
Large amplitude oscillations of contracted airway smooth muscle cause relative relaxation of the preparation. However, little is known about the effect of mechanical stretch on distal lung behaviour. Rat parenchymal strips were suspended in an organ bath and attached at one end to a force transducer and at the other end to a servo-controlled lever arm that effected length changes. Mechanical im...
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The object of this study was to investigate how changes in the contractile state of smooth muscle would modify oscillatory mechanics of tracheal muscle and lung parenchyma during agonist challenge. Guinea pig tracheal and parenchymal lung strips were suspended in an organ bath. Measurements of length (L) and tension (T) were recorded during sinusoidal oscillations under baseline conditions and ...
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The lung extracellular matrix changes rapidly with maturation. To further our understanding of the mechanisms underlying lung tissue mechanics, we studied age-related changes in mechanical properties in lung parenchymal strips from baby (10-15 days old), young ( approximately 3 wk old), and adult ( approximately 8 wk old) rats. Subpleural strips were cut and suspended in a fluid-filled organ ba...
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The viscoelastic properties of the pulmonary parenchyma change rapidly postparturition. We compared changes in mechanical properties with changes in tissue composition of rat lung parenchymal strips in three groups of Sprague-Dawley rats: baby (B; 10-14 days), young (Y; approximately 3 wk), and adult (A; approximately 8 wk). Strips were suspended in an organ bath, and resistance (R), elastance ...
متن کاملThe Role of Extracellular Matrix in Lung Diseases
Extracellular Matrix (ECM) is the biologically active connective framework extending between cells; the composition of the ECM contributes significantly to wound healing, cell proliferation, cell mobility, and cell differentiation [1]. ECM occurs in two basic forms in animal tissues: stromal matrix and basement membrane [2]. The basement membrane is a thin layer of ECM located on the basolatera...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2004
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.03.00025403